The high death rate of pancreatic cancer is attributed to the lack of reliable methods for early detection and underlying molecular mechanisms of its aggressive pathogenesis. Sims 1 Pc Download. Although MUC13, a newly identified transmembrane mucin, is known to be aberrantly expressed in ovarian and gastro-intestinal cancers, its role in pancreatic cancer is unknown. El Aprendiz De Brujo Libro Pnl Descargar on this page.
Herein, we investigated the expression profile and functions of MUC13 in pancreatic cancer progression. Download Gratis Emulators Nintendo Ds Per Psp Update there. The expression profile of MUC13 in pancreatic cancer was investigated using a recently generated monoclonal antibody (clone PPZ0020) and pancreatic tissue microarrays.
Offered in Catawiki's Lego auction: Ninjago - 2259 Skull Motorbike - 70600 Ninja Bike Chase - 70621 The Vermillion Attack. New condition, complete in unopened boxes. Oct 25, 2011. The publisher's final edited version of this article is available free at Mol Cancer Ther. See other articles in PMC that cite. The expression of MUC13 correlates with the expression/activation of HER2, PAK1, ERK, Akt, and S100A4 and the decreased expression of p53. These results show, for the first time,.
The expression of MUC13 was significantly ( P. Introduction In 2011, pancreatic cancer is estimated to be detected in more than 44,000 people and to account for more than 37,000 deaths in the United States (). With an overall 5-year survival rate of only 5%, pancreatic cancer is the fourth most lethal cancer, accounting for 6% of all cancer-related deaths in both men and women ().
Together, the aggressive nature of pancreatic cancer combined with vague symptoms and lack of screening mechanisms create a difficult disease to treat. The serum tumor marker CA19-9 may be helpful in diagnosing pancreatic cancer, but it lacks sensitivity and specificity to effectively screen asymptomatic patients (). Therefore, the identification of sensitive and specific markers is needed for early detection and subsequent treatment of pancreatic cancer. Mucins (MUC) have been identified as potential tumor markers and attractive therapeutic targets (, ). Mucins form a physical barrier which provides protection for epithelial cells under normal physiologic conditions. However, mucins may be involved in cancer development when expression, localization, or glycosylation patterns change. Such changes can lead to increased cell growth, transformation, and decreased immune surveillance (, ).